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IPAMORELIN View full size

IPAMORELIN

Ipamorelin 2mg vial

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Ipamorelin

Availability: On Backorder

£14.93

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IPAMORELIN
Rating: 4 out of 18 reviews

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  • Reviews (18)

Ipamorelin - Growth Hormone Releasing Peptide (GHRP)

Ipamorelin profile:

The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.

Description:

0.6 kDa peptide containing 5 amino acid residues.

Aib-His-D-2-Nal-D-Phe-Lys-NH2

Synonyms:

Ipamorelin, Growth Hormone Releasing Peptide, GHRP, pentapeptide.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Specificity:

Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH.

Purity:

>99.8% (HPLC analyzed).

Solubility:

Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.

Stability:

Store lyophilized peptde at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted peptde can be stored at 4 °C for a limited period of time. The lyophilized peptde remains stable until the expiry date when stored at -20 °C.

Source: Biosynthesis

Usage:

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

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Craig

03/29/2017
5
Great service from DRS-LABS

Great service from DRS
Recently purchased Sermorelin and Ipamorelin.. excellent communication from DRS-LABS, just had some shipped to Spain whilst on holiday.. no hassles and arrived in less than a week.. keep up the good work guys.

 
ludovic

03/18/2017
5
Finalement c'est bon

Désolé de mon premier message mai je ressent finalement les effet donc je recommande ce produit

 
ludovic

03/18/2017
1
Pas de ressenti

Aucun ressenti pour l'instant même après injection je ressent rien.

 
Hannes

02/25/2017
5

Ich bin sehr erstaunt und Überrascht es wirkte in Kombination mit GRF 129 & PGF Alpha 2 & MK 266 und Andarin echt Beeindruckend
Qualität Top sowie Lieferzeit und Service!

 
Hannes

02/25/2017
5

Ich bin sehr erstaunt und Überrascht es wirkte in Kombination mit GRF 129 & PGF Alpha 2 & MK 266 und Andarin echt Beeindruckend
Qualität Top sowie Lieferzeit und Service!

 
Brian

11/20/2016
5
Ipamorelin

Does what it is supposed to.
Great service from DRS.

 
Brian

09/1/2016
5
IPAMORELIN

Does what it is supposed to.
Usual great service and delivery from DRS.

 
Brian

05/20/2016
4
Ipamorelin

Usual quick delivery.
Good product - mildly uncomfortable sensation at injection site which passes very quickly.
Great value.

 
Ste

03/24/2016
5
Ipamorelin

Great quality , have tried other suppliers, but always come back here for Ipamorelin.

 
Ste

01/10/2016
5
Ipamorelin

Combining Ipa with CJC 1295w/o DAC, results were v good
Best results were with sermorelin grf 1-29

 
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