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Melanotan 2 TANEXIN

Melanotan-2 10mg vial

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Melanotan 2

£30.52

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Melanotan 2 TANEXIN
Rating: 4 out of 64 reviews

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Tanexin - Melanotan 2

Melanotan 2 profile:

The synthetic cyclic heptapeptide, Melanotan II (also known as Tanex or MT-II, developed at the University of Arizona) an analogue of alpha-melanotropin, is a receptor agonist of the Melanocortin peptide hormone, α-melanocyte-stimulating hormone (α-MSH), that stimulates the body to make melanin. Melanocortin peptides are neuropeptides derived from the precursor molecule pro-opiomelanocortin (POMC) by tissue-specific splicing; they include adrenocorticotropic hormone (ACTH) and a-melanocyte-stimulating hormone (a-MSH).1

Clinical trials have shown that MT-II safely promotes melanogenesis and aphrodisiac effects. As a result is has a potential to be developed into a tanning and libido increasing preparation. There have also been many studies on MT-II and its effectiveness as: being neurotrophic and neuroprotective; being able to increase insulin sensitivity, improve glucose tolerance as well as decrease food intake and lower body weight.1

Melanin, the dark pigment of a tan, is known to protect the body from skin damage caused by exposure to ultra-violet (UV) radiation. MT-II induces a protective tan without the need to expose the skin to harmful levels of UV radiation. Using potentiometric titration and ultraviolet (UV) spectrophotometry, MT-II has been previously evaluated for the prevention of sunlight induced cancers without the use of chemotherapy.1

Studies, alternating MT-II with Saline (placebo), for 2 consecutive weeks yielded interesting results. Mild nausea, not requiring antiemetic treatment, was reported at most MT-II dose levels as well as the onset of spontaneous, penile erections which were intermittently experienced for l-5 hours after MT-II dosing, depending on the MT-II dose. After 1 week of dosing, patients had increased pigmentation in the face and upper body. Such results demonstrate that MT-II has tanning activity with only 5 low doses every other day by subcutaneous injection.1

Alpha-melanocyte stimulating hormone (α-MSH) is a linear, tridecapeptide which is synthesized and secreted by the pars intermedia of lower vertebrate pituitary glands. α-MSH lacks corticotropic activity and instead, is used to control integumental coloration by binding to melanocortin (MC) receptors on the plasma membranes of melanocytes in the skin.2

MT-II chronically reduces body weight, without the need of long term calorific restriction.3 Obesity is characterized by increased body fat stores resulting from an imbalance between energy intake and energy expenditure. Increased adiposity causes insulin resistance. Type 2 diabetes mellitus (DM) develops when the increased demand for insulin is not compensated due to impaired pancreatic beta cells. Fat accumulation is the primary cause of insulin resistance, although studies show that the central nervous system also plays a critical role.4

The central melanocortin system is a critical regulator of energy homeostasis. Pharmacological and genetic studies have revealed pivotal roles for the central melanocortin pathway in the regulation of satiety and energy expenditure. The melanocortin receptors 3 and 4 (MC3/4 receptors) are required for optimal function of the central melanocortin system.3 These receptors regulate appetite along with numerous metabolic pathways, including thermogenesis, and lipolysis. The α-melanocyte-stimulating hormone (α-MSH) is the endogenous agonist ligand for the MC3/4 receptors. The more stable synthetic melanocortinergic peptide is the MT-II, a non-selective agonist of MC receptors.

There is evidence supporting MTII as a long-term modulator of energy balance, e.g. it can suppress appetite therefore, it may help combat obesity.3 MT-II also increases insulin sensitivity, improves glucose tolerance4, as well as being neurotrophic and neuroprotective.5

Effects of peripheral administration of MT-II, on insulin sensitivity and glucose tolerance were previously examined.4 Subcutaneous administration of MT-II had decreased food intake and body weight in OLETF rats. MT-II group showed more sensitivity to insulin compared with that allowed to eat at libitum or pair-fed group in insulin tolerance tests on day 9.4

MT-II can significantly enhance the recovery of sensory function following a crush lesion of the sciatic nerve.5 In addition, it has been also observed to possesses neuroprotective properties, as it partially protects the nerve from a toxic neuropathy induced by cisplatin.5

Several of the melanocortins, including α-MSH, have been shown to improve recovery of function after peripheral nerve damage, as well as after experimental spinal cord injury.

Description:

0.8 kDa peptide containing 7 amino acid residues.

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Synonyms:

Melanotan 2, Melanotan II, MT-2, MT-II, Melanotide, Tanexin.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Specificity:

MT-2 has an affinity to melanocortin receptors MC3R and MC4R.

Purity:

>99.8% (HPLC analyzed).

Solubility:

Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.

Stability:

Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

Source:

Chemical synthesis

Usage:

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

References:

  1. Lan EL, et al. Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide. J Pharm Sci. 1994 Aug;83(8):1081-4.
  2. Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-84.
  3. Côté I, et al. Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction. Can J Physiol Pharmacol. 2017 Feb;95(2):206-214. doi: 10.1139/cjpp-2016-0290.
  4. Banno R, et al. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides. 2004 Aug;25(8):1279-86.
  5. Ter Laak MP, et al. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur J Pharmacol. 2003 Feb 21;462(1-3):179-83.



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Tobias

06/26/2017
1
Melanotan

I Never Order here At DRS Labs again!!!! I ordered 5 Melanotan and only one is comming to me

 
Adrian

05/30/2017
5
Superb Service

Item is the best on the Market. Quick delivery and superb comms. Thankyou Drlabs

 
Claes

05/25/2017
5
melanotan2

super i do twice a week and its mind blowing better tan, sex drive and better than viagra or ciales, use 6 hours bevore intimacie and she wil be supriced! ;)

 
Joseph

04/9/2017
4
Order

Had trouble to start with and posted last review on wrong product. Although it took some time sort due to supply issues. DRS have delivered. Still waiting on other products on back order which I hope to receive soon. Thanks

 
Dayna

04/2/2017
5

I have used this product for the past 2 years now. I always buy 2 bottles and use 2 months before I go on holiday. I am faired skinned and normally burn however this product makes me go really brown and I don't burn! It is amazing and I highly recommend!

 
Leanne

03/21/2017
5
Brilliant product

Amazing results with this product, great colour when used with sunbed.
Excellent seller/service, just a shame delivery is so expensive else I'd order more often

 
Tyson

03/21/2017
5
The best tanning help you can buy... Seriously!!!

my recommended way to use Melanotan is to start off with your base layer, maybe use your local sunbed shop.
I used this method for around 4 weeks before my holiday to sunny Spain.
I ended up going there looking like I had been there for the past four weeks!
Came home with a strong, dark tan.
Start off with a low dosage tho, as I have heard taking too much can make you feel sick, as a friend of mine found out the hard way!

 
adam

03/15/2017
5
Melanotan Review

Unbelievable results
very strong
Fast delivery
Great service
High recommendation!

 
Katie

03/15/2017
5
Deep tan

Used this on sunbed to start with three weeks before my holiday, and was using on my holiday also.
I got a dark, deep tan.
Best product I have tried, definitely better than the tablet form I have used before

 
Tracy

03/7/2017
5
Awsome source!

Started off with low dosage, a lot of fake stuff out there, not this product! worked a treat. Rich, dark tan, Thank you dr labs!

 
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