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HGH HUTROPIN View full size

HGH HUTROPIN

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HGH HUTROPIN
Rating: 4 out of 28 reviews

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  • Reviews (28)

Hutropin Profile:

Human growth hormone (GH) is a proteohormone which can be found in several isoforms.1,2 Two genes encode GH located on chromosome 17q, yielding two protein products: the pituitary 22kDa GH isoform and 20kDa GH.1 The 22kDa GH-encoding gene is expressed in the pituitary gland and yields a 191 amino-acid single chain protein secreted by somatroph cells of the anterior pituitary.1,5 It acts through binding to the HGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of HGH effects.2

GH is mostly known to promote longitudinal growth in children and adolescents, but also has numerous crucial metabolic functions in adult life.3 Exogenous HGH has the well-recognised ability to restore normal rates of growth in both human and animal models of growth retardation.5

Effects of HGH on the adult organism are well established from studies with recombinant GH.2,3 The primary goal of such therapies in adults is to correct the abnormalities associated with GH deficiency. Currently the use of rGH in adults involves individualised dosing regimen based on serum IGFI levels and the absence of adverse side effects.3 However, detection of the rHGH is difficult because its amino acid sequence is identical to the major 22kDa isoform normally secreted by the pituitary; it has a very short half-life in circulation, which leads to highly variable serum levels.2

Concentration alone cannot detect the exogenous administration of hGH.2 Therefore two approaches have been developed: marker approach and isoform approach. The former analyses changes in HGH-dependent parameters like IGF1 or components of bone and collagen metabolism; the latter investigates the spectrum of molecular isoforms in circulation, i.e. pituitary produces a spectrum of homo-, hetero- and - multimers of HGH isoforms, whereas rHGH consists of the 22kDa isoform monomers only, that become predominant after rHGH administration.2 Specific immunoassays with preference for the one or the other isoform allow analysis of the relative abundance of the 22kDa isoform.1,2

The well-established benefits of GH therapy include improved body composition, surrogate markers of cardiovascular risk factors, exercise capacity, skeletal integrity and quality of life.3 Long-term continuous GH administration in GH-deficient adults leads to comparable responses in terms of bone metabolism, body composition, insulin sensitivity and lipid metabolism: it produces increased lean body mass and lipolysis, decreased fat mass, improvements in VO (2max), and maximal power output.2,3

Numerous studies have been aimed at developing more safe and stable form of HGH. For example, recent work by Wu, et al. showed that combinatorial PEGylation at specific sites (Y35, G131, and K145) can significantly reduce rGH immunogenicity and improve pharmacokinetic profile compared with mono-PEGylation, while retaining biological activity.4 They have re-examined the pharmacodynamics in hypophysectomized rats and found multi-PEGylated hGH to be much more stable than mono-PEGylated hGH proving combinatorial, precise PEGylation methods could potentially facilitate development of next-generation, long-acting hGH with low immunogenicity.4

Hutropin is manufactured by SynTech Biochem, China, and contains sterile lyophilized formulation of E.coli derived recombinant human GH (191 amino acid sequence HGH), identical to the natural growth hormone in amino acid sequence and three-dimension structure. Hutropin comes in a 10IU Hutropin HGH vial.

Description:

22 kDa protein containing 191 amino acid residues.

FPTI PLSRLFDNAM LRAHRLHQLA FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL MGRLEDGSPR TGQIFKQTYS KFDTNSHNDDALLKNYGLLY CFRKDMDKVE TFLRIVQCRS VEGSCGF

Synonyms:

HGH, Human Growth Hormone, Somatropin, Somatotropin.

Physical Appearance:

Sterile Filtered White lyophilized (freeze-dried) powder.

Specificity:

The amino acid sequence and tertiary structure of the Hutropin - somatropin (HGH) is identical to naturally produced HGH. Therefore, Hutropin HGH has an affinity to HGH receptors.

Purity:

>95% (SDS-PAGE analyzed).

Solubility:

Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.

Stability:

Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

Source: E.Coli

Usage:

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

References:

  1. Baumann, G. Growth hormone isoforms. Growth Horm IGF Res. 2009 Aug; 19(4): 333–340.
  2. Bidlingmaier M, Strasburger CJ. Growth hormone. Handb Exp Pharmacol. 2010;(195):187-200.
  3. Strasburger CJ, Vanuga P, Payer J, et al. MOD-4023, a long-acting carboxy-terminal peptide-modified human growth hormone: results of a Phase 2 study in growth hormone-deficient adults. European Journal of Endocrinology. 2016;176(3):283-294.
  4. Wu L, Chen J, Wu Y, et al. Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone. J Control Release. 2017 Mar 10;249:84-93.
  5. Bayol A, Bristow A, Charton E, Girard M, Jongen P. Somatropin and its variants: structural characterization and methods of analysis. Pharmeuropa Bio. 2004 Dec;2004(1):35-45.

 

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Jonas

03/21/2017
5
Großes HGH

Schnelle und große Muskelgewinne aus diesem HGH Produkt. Danke sehr viel DRS

 
adam

03/15/2017
5
Hgh Hutropin review

Very strong product, Nice to find a trusted site with pure products, no fake stuff!

 
David

03/15/2017
5
Wonderful product

Ordered this using live chat, very helpful, the product itself is fantastic.
Thanks for a great product

 
Steven

03/6/2017
5
Hgh Hutropin, great product

Very good results, fast delivery with fantastic live chat support!

 
edva

03/3/2017
5
Hutropin hgh

Great product, great service, fast shipping. All in one package.

 
Dee

11/24/2016
5
hutropin

brilliant. This company are very good with communication. when out of stock they do their best to keep you notified. as for product my skin has improved massively.

 
Dee

02/18/2016
5
Hgh hutropin

Brilliant absolutely brilliant. Totally recommended.

 
Gavin

01/10/2016
5
HUTROPIN

I highly recommend I pressed no by accident. I had to add another review as ths company and product are top notch

 
Gavin

01/10/2016
5
HUTROPIN

Great product
Great service
Fast delivery (2days)
Great company
Very reliable
Will be purchasing again

 
marco

01/6/2016
5
HGH Hutrophin

Tutton perfect order item arrived on time as promised.
compliments to the seriousness of the company

 
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