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MK-677 Ibutamoren Mesylate View full size

MK-677 Ibutamoren Mesylate

MK-677 25mg x 50tabs

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MK-677 Ibutamoren Mesylate
Rating: 4 out of 10 reviews

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  • Reviews (10)

MK-677 Ibutamoren Mesylate is a compound which acts as a potent, orally active GH (growth hormone) secretagogue, mimicking the action of endogenous ghrelin (ghrelin mimetic). Investigational names: Ibutamoren (MK-677, Ibutamoren Mesylate, L-163,191)

MK-677 profile:

In normal subjects dietary energy restriction results in catabolic response associated with the loss of nitrogen, decrease in IGF-I, increase in GH, and GH resistance. However, this resistance is not absolute since administration of exogenous GH will stimulate increase in IGF-I levels and nitrogen retention.

MK-677 is a non-peptide spiropiperidine and is functionally indistinguishable in vitro and in vivo from the GHRP-6. However, MK-677 stimulates GH release through a pituitary and hypothalamic receptors (different from the GH-releasing hormone receptors), and is able to sustain GH plasma levels and IGF-I release without affecting endogenous cortisol. This compound is being developed as a potential therapy in growth hormone deficient children or elderly adults. It was shown to be able to increase muscle mass and bone mineral density therefore can be used to treat frailty in the elderly. In addition, MK-677 alters metabolism of body fat so may be applied in the treatment of obesity.

Short-term oral administration of Ibutamoren may be used as adjunctive therapy in certain catabolic states: MK-677 is able to reverse protein catabolism caused by dietary caloric restriction since the degree of growth hormone stimulation is sufficient to improve nitrogen balance. In healthy adult males, Ibutamoren is more effective than GHRH, producing a mean peak GH concentration of 22.1μg/L after an oral dose of 25mg.


Description:

Formula: 2-Amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide
Formula: C27H36N4O5S
Mol. weight: 624.77
PubChem: CID 9939050
Molecular Structure:



Synonyms:

Ibutamoren, MK-677, Ibutamoren Mesylate, L-163, 191, MK0677

Physical Appearance:

White tablets.

Specificity:

MK-677 selectively binds GH secretagogue receptors in certain tissues.

Purity:

>99.9% (HPLC analyzed).

Stability:

Store at at 20 °C in dry place until the expiration date.

Source: Chemical Synthesis

Half-life: 24 hours

Usage:

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

  • Buy MK-677 (Ibutamoren) UK Online - Fast Shipping
Karl

03/15/2017
5
Proper stuff

Strong, very good product.
found myself eating a lot more

 
Josh

03/15/2017
5
Do you even lift!!!

Wow
Product amazing, improved my strength and size rapidly.

Im now looking and feeling great!
No noticeable side effects to note!

 
Hayley

03/8/2017
5

Arrived very quick, research brings exciting results!

 
Axel

03/3/2017
5
satisfied

fast shipping, good communication very recommended supplier!

 
Gonzalo

12/20/2016
5
Works great!

Worked great for me, I improved all my lifts and times, it gave me a lot of confidence and had me feeling great!

Side-effects include occasional numbness and some extreme hunger sometimes.

Will buy again.

I took it first thing in the morning, 6 days a week.

 
Arkadiusz

09/7/2016
5

Great product!! Fast shipping uk

 
Thorsten

07/5/2016
3
fast shipment

fast shipment, mk is not that good -side effects include stomachache

 
Petr

01/7/2016
5
Kosmos

Perfect product, fast shipping EU

 
Lora

03/25/2015
5

Very fast shipping (like always), thanks for that. MK-677 will also be researched soon.

 
idan

10/21/2014
5
very fast shipment

arrive 1 week after the order very suprise for worldwide ship

 
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